is it necessary to screen for celiac disease in idiopathic osteoporosis?
نویسندگان
چکیده
800x600 abstract: aim: the aim of this study was to investigate that the necessity of screening for celiac disease in idiopathic osteoporotic patients. background: osteopenia and osteoporosis are well-known and prevalent complications of celiac disease. however, the relative prevalence of celiac disease among osteoporotic populations is not known, and the benefit of screening for celiac disease among the osteoporotic population remains controversial. patients & methods: we evaluated 560 individuals, 460 with osteoporosis and 100 healthy subjects, from the rheumatology clinic in imam khomeini and shariati hospital by iga anti tissue transglutaminase (anti-ttg) for celiac disease. then individuals with positive serologic test underwent upper gi endoscopy & 2nd part duodenum biopsies. the clinical findings were evaluated in the both groups and were compared with each other. results: five (?1%) of 460 patients with osteoporosis and 1 (1%) of 100 subjects without osteoporosis had celiac disease by positive serologic & pathology results. three patients with positive serology & pathology results were female. all patients in osteoporotic group had at least one other symptom of celiac disease. two of them had anemia and others had chronic abdominal pain, recurrent oral aphtous lesion & chronic bloating. conclusions: in the present study, the prevalence of celiac disease in osteoporotic patients is not high enough to justify recommendation for serologic screening of celiac disease in all patients with idiopathic osteoporosis; but in osteoporotic patients with other celiac or gastrointestinal symptoms and signs for example iron deficiency anemia, chronic dyspepsia and bloating, constipation or diarrhea and recurrent aphtous lesions, it is necessary to evaluate for celiac disease.
منابع مشابه
Is it necessary to screen for celiac disease in adult idiopathic osteoporosis?
AIM the aim of this study was to investigate the necessity of screening for celiac disease in idiopathic osteoporotic patients. BACKGROUND Osteopenia and osteoporosis are well-known and prevalent complications of celiac disease. However, the relative prevalence of celiac disease among osteoporotic populations is not known, and the benefit of screening for celiac disease among the osteoporotic...
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Gabriel Samasca1, Diana Deleanu1, Genel Sur2, Iulia Lupan3, Alexandru Giulia4, Rahela Carpa4 1Department of Immunology and Allergology, University of Medicine and Pharmacy, Cluj-Napoca, Romania 2Department of Pediatrics II, Iuliu Hațieganu, University of Medicine and Pharmacy, Cluj-Napoca, Romania 3Department of Molecular Biology, “Babes-Bolyai” University, Cluj-Napoca, Romania 4Department of M...
متن کاملRethinking strategies to screen for celiac disease.
Celiac disease (CD) is likely an ancient disease. It is thought that CD became a health problem as people moved from a hunter-gatherer economy to farming-based economy some time during the Neolithic period and geographically in the Fertile Crescent. Indeed, the earliest description of CD is attributed to Aretaeus the Cappadocian. Cappaddocia is adjacent to the Fertile Crescent. Recent studies o...
متن کاملA biopsy is not always necessary to diagnose celiac disease.
OBJECTIVES Small intestinal histology is the criterion standard for the diagnosis of celiac disease (CD). However, results of serological tests such as anti-endomysium antibodies and anti-tissue transglutaminase antibodies (tTGA) are becoming increasingly reliable. This raises the question of whether a small intestinal biopsy is always necessary. The aim of the present study was, therefore, to ...
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عنوان ژورنال:
gastroenterology and hepatology from bed to benchجلد ۸، شماره ۲، صفحات ۲۰۱۵-۸
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